General Information of the Compound
Compound ID
CP0554859
Compound Name
4-fluoro-3-[[6-methoxy-7-[(5-methyl-1,2,4-oxadiazol-3-yl)methoxy]quinazolin-4-yl]amino]-2-methylphenol
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Structure
Formula
C20H18FN5O4
Molecular Weight
411.393
Canonical SMILES
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCc1noc(C)n1
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InChI
InChI=1S/C20H18FN5O4/c1-10-15(27)5-4-13(21)19(10)25-20-12-6-16(28-3)17(7-14(12)22-9-23-20)29-8-18-24-11(2)30-26-18/h4-7,9,27H,8H2,1-3H3,(H,22,23,25)
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InChIKey
RDOXFGHLLUYIIL-UHFFFAOYSA-N
Physicochemical Property
logP
3.80554
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
115.42
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118111994
ChEMBL ID
CHEMBL3798119
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 > 10000 nM
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