General Information of the Compound
Compound ID
CP0554278
Compound Name
3-[3-(1,2,3,6-tetrahydropyridin-4-yl)indol-1-yl]sulfonylisoquinoline
    Show/Hide
Structure
Formula
C22H19N3O2S
Molecular Weight
389.48
Canonical SMILES
O=S(=O)(c1cc2ccccc2cn1)n1cc(C2=CCNCC2)c2ccccc12
    Show/Hide
InChI
InChI=1S/C22H19N3O2S/c26-28(27,22-13-17-5-1-2-6-18(17)14-24-22)25-15-20(16-9-11-23-12-10-16)19-7-3-4-8-21(19)25/h1-9,13-15,23H,10-12H2
    Show/Hide
InChIKey
LFOMMXARKZXPCW-UHFFFAOYSA-N
Physicochemical Property
logP
3.8032
Rotatable Bonds
3
Heavy Atom Count
28
Polar Areas
63.99
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 155551219
ChEMBL ID
CHEMBL4541828
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 12 nM
   TI
   LI
   LO
   TS