General Information of the Compound
Compound ID
CP0552718
Compound Name
methyl (2S)-4-methyl-2-[[2-[[2-oxo-2-[(2S)-1-[2-(quinoline-4-carbonylamino)acetyl]pyrrolidin-2-yl]acetyl]amino]acetyl]amino]pentanoate
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Formula
C27H33N5O7
Molecular Weight
539.589
Canonical SMILES
COC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12
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InChI
InChI=1S/C27H33N5O7/c1-16(2)13-20(27(38)39-3)31-22(33)14-29-26(37)24(35)21-9-6-12-32(21)23(34)15-30-25(36)18-10-11-28-19-8-5-4-7-17(18)19/h4-5,7-8,10-11,16,20-21H,6,9,12-15H2,1-3H3,(H,29,37)(H,30,36)(H,31,33)/t20-,21-/m0/s1
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InChIKey
CGGZLVKZEXMSBK-SFTDATJTSA-N
Physicochemical Property
logP
0.3448
Rotatable Bonds
11
Heavy Atom Count
39
Polar Areas
163.87
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4847560
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01241, Prolyl endopeptidase FAP
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000090 Schneider 2 Drosophila melanogaster (Fruit fly)  1
1
IC50 = 6.7 nM
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