General Information of the Compound
Compound ID
CP0552686
Compound Name
(2R,3R,4S,5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
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Structure
Formula
C20H27N7O3
Molecular Weight
413.482
Canonical SMILES
Cc1cc(C)n(C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(NC4CCCC4)ncnc23)n1
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InChI
InChI=1S/C20H27N7O3/c1-11-7-12(2)27(25-11)8-14-16(28)17(29)20(30-14)26-10-23-15-18(21-9-22-19(15)26)24-13-5-3-4-6-13/h7,9-10,13-14,16-17,20,28-29H,3-6,8H2,1-2H3,(H,21,22,24)/t14-,16-,17-,20-/m1/s1
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InChIKey
KMOXXFGVTZFHKZ-WVSUBDOOSA-N
Physicochemical Property
logP
1.31354
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
123.14
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
10
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137637451
ChEMBL ID
CHEMBL4059994
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 115 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 14500 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 60000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 5640 nM
   TI
   LI
   LO
   TS