General Information of the Compound
Compound ID
CP0550395
Compound Name
N1,N4-bis(2-(2-(2-(2-(4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylsulfonamido)ethoxy)ethoxy)ethoxy)ethyl)terephthalamide
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Structure
Formula
C56H68Cl4N6O12S2
Molecular Weight
1223.136
Canonical SMILES
CN1CC(c2ccc(cc2)S(=O)(=O)NCCOCCOCCOCCNC(=O)c2ccc(cc2)C(=O)NCCOCCOCCOCCNS(=O)(=O)c2ccc(cc2)C2CN(C)Cc3c(Cl)cc(Cl)cc23)c2cc(Cl)cc(Cl)c2C1
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InChI
InChI=1S/C56H68Cl4N6O12S2/c1-65-35-49(47-31-43(57)33-53(59)51(47)37-65)39-7-11-45(12-8-39)79(69,70)63-17-21-75-25-29-77-27-23-73-19-15-61-55(67)41-3-5-42(6-4-41)56(68)62-16-20-74-24-28-78-30-26-76-22-18-64-80(71,72)46-13-9-40(10-14-46)50-36-66(2)38-52-48(50)32-44(58)34-54(52)60/h3-14,31-34,49-50,63-64H,15-30,35-38H2,1-2H3,(H,61,67)(H,62,68)
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InChIKey
GFNIFQOPNUJPDY-UHFFFAOYSA-N
Physicochemical Property
logP
6.971
Rotatable Bonds
32
Heavy Atom Count
80
Polar Areas
212.4
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
14
Complexity
80

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 86672371
ChEMBL ID
CHEMBL3908998
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04309, Sodium/hydrogen exchanger 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000422 OK Didelphis virginiana (North American opossum)  2
1
IC50 = 12.59 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT03762, Sodium/hydrogen exchanger 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000422 OK Didelphis virginiana (North American opossum)  1
1
IC50 = 39.81 nM
   TI
   LI
   LO
   TS