General Information of the Compound
Compound ID
CP0550043
Compound Name
(7-cyclopentyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-(2-methoxyphenyl)methanone
    Show/Hide
Structure
Formula
C23H27NO4
Molecular Weight
381.472
Canonical SMILES
COc1cc2CCN(Cc2cc1OC1CCCC1)C(=O)c1ccccc1OC
    Show/Hide
InChI
InChI=1S/C23H27NO4/c1-26-20-10-6-5-9-19(20)23(25)24-12-11-16-13-21(27-2)22(14-17(16)15-24)28-18-7-3-4-8-18/h5-6,9-10,13-14,18H,3-4,7-8,11-12,15H2,1-2H3
    Show/Hide
InChIKey
JSYWGMUQSXFHSI-UHFFFAOYSA-N
Physicochemical Property
logP
4.2237
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
48
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 122190066
ChEMBL ID
CHEMBL3617178
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01305, 3',5'-cyclic-AMP phosphodiesterase 4B
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 37000 nM
   TI
   LI
   LO
   TS