General Information of the Compound
Compound ID
CP0548680
Compound Name
4-[4-[4-[1-[(3-chlorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
    Show/Hide
Formula
C35H39ClN4O
Molecular Weight
567.177
Canonical SMILES
Clc1cccc(Cn2ccc3c(cccc23)N2CCN(CCCCOc3cccc4C(CCc34)NCC#C)CC2)c1
    Show/Hide
InChI
InChI=1S/C35H39ClN4O/c1-2-17-37-32-15-14-30-29(32)10-6-13-35(30)41-24-4-3-18-38-20-22-39(23-21-38)33-11-7-12-34-31(33)16-19-40(34)26-27-8-5-9-28(36)25-27/h1,5-13,16,19,25,32,37H,3-4,14-15,17-18,20-24,26H2
    Show/Hide
InChIKey
UYOCKTVRSMHBRW-UHFFFAOYSA-N
Physicochemical Property
logP
6.5343
Rotatable Bonds
11
Heavy Atom Count
41
Polar Areas
32.67
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
ChEMBL ID
CHEMBL4794139
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 113 nM
   TI
   LI
   LO
   TS