General Information of the Compound
Compound ID
CP0548569
Compound Name
4-[3-[4-[1-[(3-chlorophenyl)methyl]indol-4-yl]piperazin-1-yl]propoxy]-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
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Formula
C34H37ClN4O
Molecular Weight
553.15
Canonical SMILES
Clc1cccc(Cn2ccc3c(cccc23)N2CCN(CCCOc3cccc4C(CCc34)NCC#C)CC2)c1
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InChI
InChI=1S/C34H37ClN4O/c1-2-16-36-31-14-13-29-28(31)9-4-12-34(29)40-23-6-17-37-19-21-38(22-20-37)32-10-5-11-33-30(32)15-18-39(33)25-26-7-3-8-27(35)24-26/h1,3-5,7-12,15,18,24,31,36H,6,13-14,16-17,19-23,25H2
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InChIKey
ZYAFXEVOOPCAME-UHFFFAOYSA-N
Physicochemical Property
logP
6.1442
Rotatable Bonds
10
Heavy Atom Count
40
Polar Areas
32.67
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4780446
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 77 nM
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