General Information of the Compound
Compound ID
CP0548453
Compound Name
4-butyl-5-(2-sulfanylidenespiro[1H-indole-3,1'-cyclohexane]-5-yl)thiophene-2-carbonitrile
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Structure
Formula
C22H24N2S2
Molecular Weight
380.582
Canonical SMILES
CCCCc1cc(sc1-c1ccc2NC(=S)C3(CCCCC3)c2c1)C#N
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InChI
InChI=1S/C22H24N2S2/c1-2-3-7-15-12-17(14-23)26-20(15)16-8-9-19-18(13-16)22(21(25)24-19)10-5-4-6-11-22/h8-9,12-13H,2-7,10-11H2,1H3,(H,24,25)
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InChIKey
ODXOMIJQMWERID-UHFFFAOYSA-N
Physicochemical Property
logP
6.58418
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
35.82
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10429892
SID: 15449461
ChEMBL ID
CHEMBL27052
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
EC50 = 23.5 nM
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