General Information of the Compound
Compound ID
CP0547757
Compound Name
CHEMBL4225372
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Formula
C128H221N29O32
Molecular Weight
2678.347
Canonical SMILES
CC[C@](C)(NC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@H](CO)NC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)CC[C@H](NC(=O)[C@H]1CC[C@H](CNC(=O)CCCCCCCCCCCCCCCCCCC(O)=O)CC1)C(O)=O)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NC(C)(C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1CCCCC1)C(N)=O
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InChI
InChI=1S/C128H221N29O32/c1-9-128(8,156-118(179)99-73-87(160)77-157(99)120(181)98(78-158)143-105(166)80-189-79-104(165)139-61-37-65-187-67-69-188-68-66-186-64-36-60-138-103(164)54-52-92(121(182)183)148-109(170)86-49-47-85(48-50-86)76-142-102(163)45-30-22-20-18-16-14-12-10-11-13-15-17-19-21-23-31-46-106(167)168)123(185)153-95(72-84-55-62-137-63-56-84)114(175)150-94(71-83-40-28-25-29-41-83)113(174)152-97(75-126(3,4)5)116(177)151-96(74-101(131)162)115(176)145-90(42-32-33-57-129)117(178)155-127(6,7)122(184)154-107(81(2)159)119(180)147-89(44-35-59-141-125(135)136)110(171)146-91(51-53-100(130)161)112(173)144-88(43-34-58-140-124(133)134)111(172)149-93(108(132)169)70-82-38-26-24-27-39-82/h55-56,62-63,81-83,85-99,107,158-160H,9-54,57-61,64-80,129H2,1-8H3,(H2,130,161)(H2,131,162)(H2,132,169)(H,138,164)(H,139,165)(H,142,163)(H,143,166)(H,144,173)(H,145,176)(H,146,171)(H,147,180)(H,148,170)(H,149,172)(H,150,175)(H,151,177)(H,152,174)(H,153,185)(H,154,184)(H,155,178)(H,156,179)(H,167,168)(H,182,183)(H4,133,134,140)(H4,135,136,141)/t81-,85-,86-,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99-,107+,128+/m1/s1
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InChIKey
JTUCQWKQGNQFDD-XHCQOMBHSA-N
Physicochemical Property
logP
-0.41216
Rotatable Bonds
99
Heavy Atom Count
189
Polar Areas
979.2
Hydrogen Bond Donor Count
32
Hydrogen Bond Acceptor Count
34
Complexity
189

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4225372
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01611, Neuropeptide Y receptor type 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 13 nM
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