General Information of the Compound
Compound ID
CP0547305
Compound Name
4-[6-[2-(6-ethenylpyridin-3-yl)ethynyl]benzimidazol-1-yl]pyrimidin-2-amine
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Structure
Formula
C20H14N6
Molecular Weight
338.374
Canonical SMILES
Nc1nccc(n1)-n1cnc2ccc(cc12)C#Cc1ccc(C=C)nc1
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InChI
InChI=1S/C20H14N6/c1-2-16-7-5-15(12-23-16)4-3-14-6-8-17-18(11-14)26(13-24-17)19-9-10-22-20(21)25-19/h2,5-13H,1H2,(H2,21,22,25)
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InChIKey
PJTPLBKTGIOSGB-UHFFFAOYSA-N
Physicochemical Property
logP
2.8355
Rotatable Bonds
2
Heavy Atom Count
26
Polar Areas
82.51
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168280816
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03652, Mitogen-activated protein kinase kinase kinase 14
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 79432.82 nM
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