General Information of the Compound
Compound ID
CP0546256
Compound Name
1-(2-bromophenyl)sulfonyl-5-methoxy-3-[(4-methyl-1,4-diazepan-1-yl)methyl]indole
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Structure
Formula
C22H26BrN3O3S
Molecular Weight
492.439
Canonical SMILES
COc1ccc2n(cc(CN3CCCN(C)CC3)c2c1)S(=O)(=O)c1ccccc1Br
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InChI
InChI=1S/C22H26BrN3O3S/c1-24-10-5-11-25(13-12-24)15-17-16-26(21-9-8-18(29-2)14-19(17)21)30(27,28)22-7-4-3-6-20(22)23/h3-4,6-9,14,16H,5,10-13,15H2,1-2H3
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InChIKey
LOCMTOJHSFNZMI-UHFFFAOYSA-N
Physicochemical Property
logP
3.7869
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
54.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137648172
ChEMBL ID
CHEMBL4083289
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 5.7 nM
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