General Information of the Compound
Compound ID
CP0546148
Compound Name
(3R,7R,9R,20R)-11-hydroxy-20-[(1R)-1-hydroxyethyl]-3,7,9-trimethyl-4,8-dioxa-21-azahexacyclo[10.9.1.02,10.03,7.016,22.017,21]docosa-1,10,12(22),14,16-pentaene-5,13-dione
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Structure
Formula
C24H25NO6
Molecular Weight
423.465
Canonical SMILES
C[C@@H](O)[C@H]1CCc2c3C=CC(=O)c4c(O)c5[C@@H](C)O[C@]6(C)CC(=O)O[C@]6(C)c5c(n12)c34
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InChI
InChI=1S/C24H25NO6/c1-10(26)13-6-7-14-12-5-8-15(27)19-18(12)21(25(13)14)20-17(22(19)29)11(2)30-23(3)9-16(28)31-24(20,23)4/h5,8,10-11,13,26,29H,6-7,9H2,1-4H3/t10-,11-,13-,23-,24-/m1/s1
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InChIKey
UABXYBZOZRLKEK-XNGWIOIMSA-N
Physicochemical Property
logP
3.4365
Rotatable Bonds
1
Heavy Atom Count
31
Polar Areas
97.99
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168270147
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000113 SW620/AD300 Homo sapiens (Human)  1
1
IC50 = 7580 nM
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