General Information of the Compound
Compound ID
CP0545958
Compound Name
N-[3-[3-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcyclopropanecarboxamide
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Structure
Formula
C22H25N3O3S2
Molecular Weight
443.594
Canonical SMILES
CC(C)Cc1cc(c(s1)S(=O)(=O)NC(=O)C1CC1)-c1cccc(Cn2ccnc2)c1
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InChI
InChI=1S/C22H25N3O3S2/c1-15(2)10-19-12-20(22(29-19)30(27,28)24-21(26)17-6-7-17)18-5-3-4-16(11-18)13-25-9-8-23-14-25/h3-5,8-9,11-12,14-15,17H,6-7,10,13H2,1-2H3,(H,24,26)
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InChIKey
UGWCJNMLHXMZAW-UHFFFAOYSA-N
Physicochemical Property
logP
4.0733
Rotatable Bonds
8
Heavy Atom Count
30
Polar Areas
81.06
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145976532
ChEMBL ID
CHEMBL4203624
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01553, Type-2 angiotensin II receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 340 nM
   TI
   LI
   LO
   TS