General Information of the Compound
Compound ID
CP0545342
Compound Name
4-N-[[1-[4-cyano-3-(trifluoromethyl)phenyl]pyrazol-3-yl]methyl]-2-fluoro-1-N-methylbenzene-1,4-dicarboxamide
    Show/Hide
Structure
Formula
C21H15F4N5O2
Molecular Weight
445.376
Canonical SMILES
CNC(=O)c1ccc(cc1F)C(=O)NCc1ccn(n1)-c1ccc(C#N)c(c1)C(F)(F)F
    Show/Hide
InChI
InChI=1S/C21H15F4N5O2/c1-27-20(32)16-5-3-12(8-18(16)22)19(31)28-11-14-6-7-30(29-14)15-4-2-13(10-26)17(9-15)21(23,24)25/h2-9H,11H2,1H3,(H,27,32)(H,28,31)
    Show/Hide
InChIKey
BANASQKGMMDPQV-UHFFFAOYSA-N
Physicochemical Property
logP
3.19148
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
99.81
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 168274510
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00894, Androgen receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL001054 LNCap-ARR2PB-eGFP Homo sapiens (Human)  1
1
IC50 > 25000 nM
   TI
   LI
   LO
   TS