General Information of the Compound
Compound ID
CP0543261
Compound Name
N-[2-[[3-(2,6-dichloro-3,5-dimethoxybenzoyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]-5-(2-methoxyethoxy)phenyl]prop-2-enamide
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Structure
Formula
C28H26Cl2N4O6
Molecular Weight
585.444
Canonical SMILES
COCCOc1ccc(Nc2ccc3c(c[nH]c3n2)C(=O)c2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
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InChI
InChI=1S/C28H26Cl2N4O6/c1-5-23(35)33-19-12-15(40-11-10-37-2)6-8-18(19)32-22-9-7-16-17(14-31-28(16)34-22)27(36)24-25(29)20(38-3)13-21(39-4)26(24)30/h5-9,12-14H,1,10-11H2,2-4H3,(H,33,35)(H2,31,32,34)
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InChIKey
HWBHDXLQYYVOKZ-UHFFFAOYSA-N
Physicochemical Property
logP
6.0112
Rotatable Bonds
12
Heavy Atom Count
40
Polar Areas
123.8
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168288332
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01343, Fibroblast growth factor receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000012 Sf21 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 6.7 nM
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