General Information of the Compound
Compound ID
CP0540201
Compound Name
[4-[(3S,4S)-4-[(3,4-dichlorophenyl)methyl]-3-ethenylpiperidin-1-yl]piperidin-1-yl]-quinolin-6-ylmethanone
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Structure
Formula
C29H31Cl2N3O
Molecular Weight
508.493
Canonical SMILES
Clc1ccc(C[C@H]2CCN(C[C@H]2C=C)C2CCN(CC2)C(=O)c2ccc3ncccc3c2)cc1Cl
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InChI
InChI=1S/C29H31Cl2N3O/c1-2-21-19-34(13-9-22(21)16-20-5-7-26(30)27(31)17-20)25-10-14-33(15-11-25)29(35)24-6-8-28-23(18-24)4-3-12-32-28/h2-8,12,17-18,21-22,25H,1,9-11,13-16,19H2/t21-,22-/m1/s1
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InChIKey
HDRXESCDVUCCBX-FGZHOGPDSA-N
Physicochemical Property
logP
6.513
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
36.44
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11386642
SID: 16480690
ChEMBL ID
CHEMBL178887
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01215, C-C chemokine receptor type 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000808 Y3-Ag 1.2.3 Rattus norvegicus (Rat)  1
1
Ki = 23 nM
   TI
   LI
   LO
   TS