General Information of the Compound
Compound ID
CP0539513
Compound Name
3-[[3,5-bis(trifluoromethyl)phenyl]methyl]-N-(3-methylphenyl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxamide
    Show/Hide
Structure
Formula
C24H22F6N4O3
Molecular Weight
528.453
Canonical SMILES
Cc1cccc(NC(=O)N2CCC3(CC2)NC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C3=O)c1
    Show/Hide
InChI
InChI=1S/C24H22F6N4O3/c1-14-3-2-4-18(9-14)31-20(36)33-7-5-22(6-8-33)19(35)34(21(37)32-22)13-15-10-16(23(25,26)27)12-17(11-15)24(28,29)30/h2-4,9-12H,5-8,13H2,1H3,(H,31,36)(H,32,37)
    Show/Hide
InChIKey
JADGYJSQQQKTON-UHFFFAOYSA-N
Physicochemical Property
logP
5.15112
Rotatable Bonds
3
Heavy Atom Count
37
Polar Areas
81.75
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 44318565
ChEMBL ID
CHEMBL84161
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 45.71 nM
   TI
   LI
   LO
   TS