General Information of the Compound
Compound ID
CP0539246
Compound Name
US8618114, 1.2.10(3)
    Show/Hide
Structure
Formula
C19H17N5O3S
Molecular Weight
395.444
Canonical SMILES
CNc1nn2c(OC)cc(nc2c1S(=O)(=O)c1ccccc1)-c1cccnc1
    Show/Hide
InChI
InChI=1S/C19H17N5O3S/c1-20-18-17(28(25,26)14-8-4-3-5-9-14)19-22-15(13-7-6-10-21-12-13)11-16(27-2)24(19)23-18/h3-12H,1-2H3,(H,20,23)
    Show/Hide
InChIKey
RQGZCEUPKJEOAP-UHFFFAOYSA-N
Physicochemical Property
logP
2.6744
Rotatable Bonds
5
Heavy Atom Count
28
Polar Areas
98.48
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 58357768
ChEMBL ID
CHEMBL3670293
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 12 nM
   TI
   LI
   LO
   TS