General Information of the Compound
Compound ID
CP0538801
Compound Name
5-chloro-N-[[1-[4-[[4-(dimethylamino)-4-oxo-3,3-diphenylbutyl]amino]butyl]pyrrolidin-2-yl]methyl]-3-ethyl-2-hydroxy-6-methoxybenzamide
    Show/Hide
Formula
C37H49ClN4O4
Molecular Weight
649.276
Canonical SMILES
CCc1cc(Cl)c(OC)c(C(=O)NCC2CCCN2CCCCNCCC(C(=O)N(C)C)(c2ccccc2)c2ccccc2)c1O
    Show/Hide
InChI
InChI=1S/C37H49ClN4O4/c1-5-27-25-31(38)34(46-4)32(33(27)43)35(44)40-26-30-19-14-24-42(30)23-13-12-21-39-22-20-37(36(45)41(2)3,28-15-8-6-9-16-28)29-17-10-7-11-18-29/h6-11,15-18,25,30,39,43H,5,12-14,19-24,26H2,1-4H3,(H,40,44)
    Show/Hide
InChIKey
ASFIQZWALJTDCY-UHFFFAOYSA-N
Physicochemical Property
logP
5.6452
Rotatable Bonds
16
Heavy Atom Count
46
Polar Areas
94.14
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
ChEMBL ID
CHEMBL5075990
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00943, D(3) dopamine receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 1513.56 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  3
1
EC50 = 208.93 nM
   TI
   LI
   LO
   TS
2
EC50 = 478.63 nM
   TI
   LI
   LO
   TS
3
EC50 = 2137.96 nM
   TI
   LI
   LO
   TS