General Information of the Compound
Compound ID
CP0538282
Compound Name
(2S)-24-(azetidin-1-yl)-11-fluoro-21-methyl-15-oxa-7,18,21,25,27,28-hexazapentacyclo[24.2.1.02,7.09,14.022,27]nonacosa-1(28),9(14),10,12,22,24,26(29)-heptaen-8-one
    Show/Hide
Structure
Formula
C26H32FN7O2
Molecular Weight
493.587
Canonical SMILES
CN1CCNCCOc2ccc(F)cc2C(=O)N2CCCC[C@H]2c2cc3nc(cc1n3n2)N1CCC1
    Show/Hide
InChI
InChI=1S/C26H32FN7O2/c1-31-13-8-28-9-14-36-22-7-6-18(27)15-19(22)26(35)33-12-3-2-5-21(33)20-16-24-29-23(32-10-4-11-32)17-25(31)34(24)30-20/h6-7,15-17,21,28H,2-5,8-14H2,1H3/t21-/m0/s1
    Show/Hide
InChIKey
PDUPJNVSFYJINX-NRFANRHFSA-N
Physicochemical Property
logP
2.8641
Rotatable Bonds
1
Heavy Atom Count
36
Polar Areas
78.24
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 154969946
ChEMBL ID
CHEMBL4753413
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06676, Fusion glycoprotein F0
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 1.4 nM
   TI
   LI
   LO
   TS