General Information of the Compound
Compound ID
CP0537790
Compound Name
4-[[5-(1,6-dimethylpyrazolo[3,4-b]pyridin-4-yl)-3-methylpyridin-2-yl]oxymethyl]bicyclo[2.2.2]octan-1-amine
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Formula
C23H29N5O
Molecular Weight
391.519
Canonical SMILES
Cc1cc(-c2cnc(OCC34CCC(N)(CC3)CC4)c(C)c2)c2cnn(C)c2n1
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InChI
InChI=1S/C23H29N5O/c1-15-10-17(18-11-16(2)27-20-19(18)13-26-28(20)3)12-25-21(15)29-14-22-4-7-23(24,8-5-22)9-6-22/h10-13H,4-9,14,24H2,1-3H3
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InChIKey
SUPJVKWVZUUSFT-UHFFFAOYSA-N
Physicochemical Property
logP
4.07764
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
78.85
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4762866
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02546, Toll-like receptor 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 2 nM
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