General Information of the Compound
Compound ID
CP0536643
Compound Name
(2S)-2-[[(4S,7S,10S,13R,18R)-7-(4-aminobutyl)-18-[[(2S)-2-amino-3-carboxypropanoyl]amino]-10-benzyl-4-(1H-indol-3-ylmethyl)-2,5,8,11-tetraoxo-15,16-dithia-3,6,9,12,19-pentazatricyclo[17.7.0.020,25]hexacosane-13-carbonyl]amino]-3-methylbutanoic acid
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Structure
Formula
C49H68N10O10S2
Molecular Weight
1021.277
Canonical SMILES
CC(C)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](N)CC(O)=O)N2C3CCCCC3CC2C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O
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InChI
InChI=1S/C49H68N10O10S2/c1-27(2)42(49(68)69)58-47(66)37-25-70-71-26-40(57-43(62)32(51)23-41(60)61)59-38-18-9-6-14-29(38)22-39(59)48(67)55-36(21-30-24-52-33-16-8-7-15-31(30)33)46(65)53-34(17-10-11-19-50)44(63)54-35(45(64)56-37)20-28-12-4-3-5-13-28/h3-5,7-8,12-13,15-16,24,27,29,32,34-40,42,52H,6,9-11,14,17-23,25-26,50-51H2,1-2H3,(H,53,65)(H,54,63)(H,55,67)(H,56,64)(H,57,62)(H,58,66)(H,60,61)(H,68,69)/t29?,32-,34-,35-,36-,37-,38?,39?,40+,42-/m0/s1
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InChIKey
RRUARFFYWSXXRD-MHOITHAUSA-N
Physicochemical Property
logP
1.5191
Rotatable Bonds
16
Heavy Atom Count
71
Polar Areas
320.27
Hydrogen Bond Donor Count
11
Hydrogen Bond Acceptor Count
13
Complexity
71

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44417527
ChEMBL ID
CHEMBL415850
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02463, Urotensin-2 receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki < 10000 nM
   TI
   LI
   LO
   TS