General Information of the Compound
Compound ID
CP0536132
Compound Name
(6R,7S,7aR)-2-benzyl-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-7-(4-fluorophenyl)-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazol-3-one
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Structure
Formula
C29H25F7N2O2
Molecular Weight
566.517
Canonical SMILES
C[C@@H](O[C@H]1CN2[C@@H](CN(Cc3ccccc3)C2=O)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C29H25F7N2O2/c1-17(20-11-21(28(31,32)33)13-22(12-20)29(34,35)36)40-25-16-38-24(26(25)19-7-9-23(30)10-8-19)15-37(27(38)39)14-18-5-3-2-4-6-18/h2-13,17,24-26H,14-16H2,1H3/t17-,24+,25+,26+/m1/s1
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InChIKey
UGDZQVXRBCKAQS-XRNKBYASSA-N
Physicochemical Property
logP
7.4133
Rotatable Bonds
6
Heavy Atom Count
40
Polar Areas
32.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44456847
ChEMBL ID
CHEMBL270114
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2.7 nM
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