General Information of the Compound
Compound ID
CP0534670
Compound Name
(S)-3-(4-(2,6-dichlorobenzyloxy)phenyl)-2-((4R,5R)-5-(thiophen-2-ylmethylcarbamoyl)-1,3-dioxolane-4-carboxamido)propanoic acid
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Structure
Formula
C26H24Cl2N2O7S
Molecular Weight
579.458
Canonical SMILES
OC(=O)[C@H](Cc1ccc(OCc2c(Cl)cccc2Cl)cc1)NC(=O)[C@@H]1OCO[C@H]1C(=O)NCc1cccs1
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InChI
InChI=1S/C26H24Cl2N2O7S/c27-19-4-1-5-20(28)18(19)13-35-16-8-6-15(7-9-16)11-21(26(33)34)30-25(32)23-22(36-14-37-23)24(31)29-12-17-3-2-10-38-17/h1-10,21-23H,11-14H2,(H,29,31)(H,30,32)(H,33,34)/t21-,22+,23+/m0/s1
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InChIKey
QISZKMMCJDRPAF-YTFSRNRJSA-N
Physicochemical Property
logP
3.8037
Rotatable Bonds
11
Heavy Atom Count
38
Polar Areas
123.19
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49865946
ChEMBL ID
CHEMBL1224183
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01186, Integrin alpha-4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 700 nM
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