General Information of the Compound
Compound ID
CP0534627
Compound Name
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-2,2-dimethylpropanamide
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Structure
Formula
C27H28FN3O2
Molecular Weight
445.538
Canonical SMILES
C[C@H](NC(=O)C(C)(C)C)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(F)cc1)c1ccccc1
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InChI
InChI=1S/C27H28FN3O2/c1-18(30-26(32)27(2,3)4)25(19-8-6-5-7-9-19)33-23-14-15-24-20(16-23)17-29-31(24)22-12-10-21(28)11-13-22/h5-18,25H,1-4H3,(H,30,32)/t18-,25-/m0/s1
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InChIKey
JZIVIKFFTCIHGU-BVZFJXPGSA-N
Physicochemical Property
logP
5.8355
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
56.15
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25011854
SID: 56355240
ChEMBL ID
CHEMBL3970276
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00967, Glucocorticoid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000464 ChaGo-K-1 Homo sapiens (Human)  1
1
IC50 = 0.66 nM
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