General Information of the Compound
Compound ID
CP0533531
Compound Name
4-[4-(2-aminopyrrolo[2,3-d]pyrimidin-7-yl)pyridin-2-yl]-2-hydroxy-2-methyl-1-pyrrolidin-1-ylbut-3-yn-1-one
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Structure
Formula
C20H20N6O2
Molecular Weight
376.42
Canonical SMILES
CC(O)(C#Cc1cc(ccn1)-n1ccc2cnc(N)nc12)C(=O)N1CCCC1
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InChI
InChI=1S/C20H20N6O2/c1-20(28,18(27)25-9-2-3-10-25)7-4-15-12-16(5-8-22-15)26-11-6-14-13-23-19(21)24-17(14)26/h5-6,8,11-13,28H,2-3,9-10H2,1H3,(H2,21,23,24)
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InChIKey
XFQIPYSYVGZULQ-UHFFFAOYSA-N
Physicochemical Property
logP
1.1226
Rotatable Bonds
2
Heavy Atom Count
28
Polar Areas
110.16
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 141758965
ChEMBL ID
CHEMBL4568402
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03652, Mitogen-activated protein kinase kinase kinase 14
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 6160 nM
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