General Information of the Compound
Compound ID
CP0533357
Compound Name
5-butyl-9-(1-(2,6-dimethylbenzoyl)piperidin-4-yl)-3-((tetrahydro-2H-pyran-4-yl)methyl)-1-oxa-3,9-diazaspiro[5.5]undecan-2-one
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Structure
Formula
C32H49N3O4
Molecular Weight
539.761
Canonical SMILES
CCCCC1CN(CC2CCOCC2)C(=O)OC11CCN(CC1)C1CCN(CC1)C(=O)c1c(C)cccc1C
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InChI
InChI=1S/C32H49N3O4/c1-4-5-9-27-23-35(22-26-12-20-38-21-13-26)31(37)39-32(27)14-18-33(19-15-32)28-10-16-34(17-11-28)30(36)29-24(2)7-6-8-25(29)3/h6-8,26-28H,4-5,9-23H2,1-3H3
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InChIKey
BBKNZDXWDHCIOQ-UHFFFAOYSA-N
Physicochemical Property
logP
5.42784
Rotatable Bonds
7
Heavy Atom Count
39
Polar Areas
62.32
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11215950
ChEMBL ID
CHEMBL1078014
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 89 nM
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