General Information of the Compound
Compound ID
CP0532353
Compound Name
1-[[3,5-dimethyl-1-[[2-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]methyl-methylamino]-3-(4-ethoxyphenoxy)propan-2-ol
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Structure
Formula
C26H32F3N3O3
Molecular Weight
491.554
Canonical SMILES
CCOc1ccc(OCC(O)CN(C)Cc2c(C)nn(Cc3ccccc3C(F)(F)F)c2C)cc1
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InChI
InChI=1S/C26H32F3N3O3/c1-5-34-22-10-12-23(13-11-22)35-17-21(33)15-31(4)16-24-18(2)30-32(19(24)3)14-20-8-6-7-9-25(20)26(27,28)29/h6-13,21,33H,5,14-17H2,1-4H3
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InChIKey
SPHSDWQWEHPJGB-UHFFFAOYSA-N
Physicochemical Property
logP
4.83744
Rotatable Bonds
11
Heavy Atom Count
35
Polar Areas
59.75
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 53363511
SID: 125266437
ChEMBL ID
CHEMBL1824692
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03041, Toll-like receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000014 RAW 264.7 Mus musculus (Mouse)  1
1
IC50 = 32100 nM
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   LI
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