General Information of the Compound
Compound ID
CP0531964
Compound Name
4-[(2S)-2-(1,6-dimethylbenzimidazol-2-yl)-2-[2,5-dioxo-3-(4-phenoxyphenyl)imidazolidin-1-yl]ethyl]-N,N-diethylbenzamide
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Structure
Formula
C37H37N5O4
Molecular Weight
615.734
Canonical SMILES
CCN(CC)C(=O)c1ccc(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)cc1
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InChI
InChI=1S/C37H37N5O4/c1-5-40(6-2)36(44)27-15-13-26(14-16-27)23-33(35-38-31-21-12-25(3)22-32(31)39(35)4)42-34(43)24-41(37(42)45)28-17-19-30(20-18-28)46-29-10-8-7-9-11-29/h7-22,33H,5-6,23-24H2,1-4H3/t33-/m0/s1
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InChIKey
OEZWJHVEIHQEOG-XIFFEERXSA-N
Physicochemical Property
logP
6.90862
Rotatable Bonds
10
Heavy Atom Count
46
Polar Areas
87.98
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
46

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155510835
ChEMBL ID
CHEMBL4434668
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01286, Bile acid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000148 Huh-7 Homo sapiens (Human)  1
1
IC50 = 1101 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2800 nM