General Information of the Compound
Compound ID
CP0531745
Compound Name
N-quinolin-8-yl-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
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Structure
Formula
C26H22N6O2
Molecular Weight
450.502
Canonical SMILES
O=C(Nc1cccc2cccnc12)N1CCC(CC1)c1nc(no1)-c1ccc2ccccc2n1
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InChI
InChI=1S/C26H22N6O2/c33-26(29-21-9-3-6-18-7-4-14-27-23(18)21)32-15-12-19(13-16-32)25-30-24(31-34-25)22-11-10-17-5-1-2-8-20(17)28-22/h1-11,14,19H,12-13,15-16H2,(H,29,33)
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InChIKey
ODWVAYLTSRETAK-UHFFFAOYSA-N
Physicochemical Property
logP
5.2445
Rotatable Bonds
3
Heavy Atom Count
34
Polar Areas
97.04
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
6
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44628620
SID: 87555847
ChEMBL ID
CHEMBL1823834
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 1300 nM
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