General Information of the Compound
Compound ID
CP0530661
Compound Name
(1R,2S,3S)-3-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)-N-(pyridin-3-ylmethyl)cyclopentanamine
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Structure
Formula
C27H25F7N2O
Molecular Weight
526.496
Canonical SMILES
C[C@@H](O[C@H]1CC[C@@H](NCc2cccnc2)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C27H25F7N2O/c1-16(19-11-20(26(29,30)31)13-21(12-19)27(32,33)34)37-24-9-8-23(36-15-17-3-2-10-35-14-17)25(24)18-4-6-22(28)7-5-18/h2-7,10-14,16,23-25,36H,8-9,15H2,1H3/t16-,23-,24+,25+/m1/s1
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InChIKey
HYZLLOJCJGJTLA-AMKSYCFISA-N
Physicochemical Property
logP
7.4405
Rotatable Bonds
7
Heavy Atom Count
37
Polar Areas
34.15
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44415947
ChEMBL ID
CHEMBL214118
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.6 nM
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