General Information of the Compound
Compound ID
CP0529649
Compound Name
2-(5-methoxy-3-oxo-1H-isoindol-2-yl)-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-4-carboxamide
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Structure
Formula
C23H23N5O3S
Molecular Weight
449.536
Canonical SMILES
COc1ccc2CN(C(=O)c2c1)c1nc(cs1)C(=O)Nc1ccccc1N1CCNCC1
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InChI
InChI=1S/C23H23N5O3S/c1-31-16-7-6-15-13-28(22(30)17(15)12-16)23-26-19(14-32-23)21(29)25-18-4-2-3-5-20(18)27-10-8-24-9-11-27/h2-7,12,14,24H,8-11,13H2,1H3,(H,25,29)
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InChIKey
ZLFQOGCIPAWQRO-UHFFFAOYSA-N
Physicochemical Property
logP
2.974
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
86.8
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59332395
SID: 163684130
ChEMBL ID
CHEMBL2381248
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00865, Serine/threonine-protein kinase Chk1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000043 U2OS Homo sapiens (Human)  1
1
EC50 = 250 nM
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