General Information of the Compound
Compound ID
CP0529265
Compound Name
US9062070, 14
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Structure
Formula
C27H29N7O4
Molecular Weight
515.574
Canonical SMILES
O=C(C1CCCc2nc(ccc12)-n1cnnn1)N1CCN2C[C@H](OC[C@@H]2C1)c1ccc2C(=O)OCCc2c1
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InChI
InChI=1S/C27H29N7O4/c35-26(22-2-1-3-23-21(22)6-7-25(29-23)34-16-28-30-31-34)33-10-9-32-14-24(38-15-19(32)13-33)18-4-5-20-17(12-18)8-11-37-27(20)36/h4-7,12,16,19,22,24H,1-3,8-11,13-15H2/t19-,22?,24-/m0/s1
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InChIKey
GTMLLAPUMAOJLN-UIEAFCHPSA-N
Physicochemical Property
logP
1.4744
Rotatable Bonds
3
Heavy Atom Count
38
Polar Areas
115.57
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 90295555
ChEMBL ID
CHEMBL3659102
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03661, ATP-sensitive inward rectifier potassium channel 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 210 nM
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