General Information of the Compound
Compound ID
CP0529184
Compound Name
US9181253, 128
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Structure
Formula
C19H18ClF2N5O3
Molecular Weight
437.834
Canonical SMILES
OCc1cc(F)c(F)cc1CNc1nc(Cl)nc2n(cnc12)[C@]12C[C@H]1[C@@H](O)[C@@H](O)C2
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InChI
InChI=1S/C19H18ClF2N5O3/c20-18-25-16(23-5-8-1-11(21)12(22)2-9(8)6-28)14-17(26-18)27(7-24-14)19-3-10(19)15(30)13(29)4-19/h1-2,7,10,13,15,28-30H,3-6H2,(H,23,25,26)/t10-,13-,15+,19-/m0/s1
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InChIKey
FCXFKNMITJNUQK-QUPAPELASA-N
Physicochemical Property
logP
1.703
Rotatable Bonds
5
Heavy Atom Count
30
Polar Areas
116.32
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
8
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 121494162
ChEMBL ID
CHEMBL3890609
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000814 Mt2-4 Homo sapiens (Human)  1
1
Ki = 1910 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000814 Mt2-4 Homo sapiens (Human)  1
1
Ki = 7510 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000814 Mt2-4 Homo sapiens (Human)  1
1
Ki = 40.4 nM
   TI
   LI
   LO
   TS