General Information of the Compound
Compound ID
CP0529145
Compound Name
2-[4-(4-acetamidophenyl)-6-amino-3,5-dicyanopyridin-2-yl]sulfanylacetamide
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Structure
Formula
C17H14N6O2S
Molecular Weight
366.406
Canonical SMILES
CC(=O)Nc1ccc(cc1)-c1c(C#N)c(N)nc(SCC(N)=O)c1C#N
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InChI
InChI=1S/C17H14N6O2S/c1-9(24)22-11-4-2-10(3-5-11)15-12(6-18)16(21)23-17(13(15)7-19)26-8-14(20)25/h2-5H,8H2,1H3,(H2,20,25)(H2,21,23)(H,22,24)
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InChIKey
NIGOXEMFVICBOV-UHFFFAOYSA-N
Physicochemical Property
logP
1.60996
Rotatable Bonds
5
Heavy Atom Count
26
Polar Areas
158.68
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 21893339
ChEMBL ID
CHEMBL4207286
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 572 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 164 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 742 nM
   TI
   LI
   LO
   TS