General Information of the Compound
Compound ID
CP0528298
Compound Name
17beta-Hydroxy-11beta-[4-(9-hydroxy-1-methyl-6,9-dioxo-1-aza-5-oxa-nonyl)-phenyl]-17alpha-(1-propinyl)-estra-4,9-dien-3-one
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Structure
Formula
C35H43NO6
Molecular Weight
573.73
Canonical SMILES
CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCOC(=O)CCC(O)=O
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InChI
InChI=1S/C35H43NO6/c1-4-17-35(41)18-16-30-28-12-8-24-21-26(37)11-13-27(24)33(28)29(22-34(30,35)2)23-6-9-25(10-7-23)36(3)19-5-20-42-32(40)15-14-31(38)39/h6-7,9-10,21,28-30,41H,5,8,11-16,18-20,22H2,1-3H3,(H,38,39)/t28-,29+,30-,34-,35-/m0/s1
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InChIKey
SIIIPWWSEADMPU-CTBBFHLNSA-N
Physicochemical Property
logP
5.5748
Rotatable Bonds
9
Heavy Atom Count
42
Polar Areas
104.14
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25231979
SID: 57583931
ChEMBL ID
CHEMBL446933
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 2.1 nM
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