General Information of the Compound
Compound ID
CP0528083
Compound Name
(S)-5-((3S,4R)-3-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)pyrrolidine-1-carbonyl)-1-methylpyrrolidin-2-one
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Structure
Formula
C26H25F7N2O3
Molecular Weight
546.483
Canonical SMILES
C[C@@H](O[C@@H]1CN(C[C@H]1c1ccc(F)cc1)C(=O)[C@@H]1CCC(=O)N1C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C26H25F7N2O3/c1-14(16-9-17(25(28,29)30)11-18(10-16)26(31,32)33)38-22-13-35(24(37)21-7-8-23(36)34(21)2)12-20(22)15-3-5-19(27)6-4-15/h3-6,9-11,14,20-22H,7-8,12-13H2,1-2H3/t14-,20+,21+,22-/m1/s1
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InChIKey
WAPJPHDEEIUMOL-WBBCYVCWSA-N
Physicochemical Property
logP
5.5563
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
49.85
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44444646
ChEMBL ID
CHEMBL248748
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.12 nM
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