General Information of the Compound
Compound ID
CP0525976
Compound Name
ethyl 4-[4-[7-amino-2-(furan-2-yl)-[1,3]thiazolo[5,4-d]pyrimidin-5-yl]piperazin-1-yl]benzoate
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Structure
Formula
C22H22N6O3S
Molecular Weight
450.524
Canonical SMILES
CCOC(=O)c1ccc(cc1)N1CCN(CC1)c1nc(N)c2nc(sc2n1)-c1ccco1
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InChI
InChI=1S/C22H22N6O3S/c1-2-30-21(29)14-5-7-15(8-6-14)27-9-11-28(12-10-27)22-25-18(23)17-20(26-22)32-19(24-17)16-4-3-13-31-16/h3-8,13H,2,9-12H2,1H3,(H2,23,25,26)
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InChIKey
KRHWODOVQMCRFB-UHFFFAOYSA-N
Physicochemical Property
logP
3.4318
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
110.61
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156017042
ChEMBL ID
CHEMBL4642713
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 4536 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 279 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  2
1
IC50 = 334 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 2679 nM
   TI
   LI
   LO
   TS