General Information of the Compound
Compound ID
CP0524582
Compound Name
US9018371, 8
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Structure
Formula
C20H18ClN5O2S
Molecular Weight
427.917
Canonical SMILES
OC1CS[C@H]([C@H]1O)n1cnc2c(NCc3cccc4ccccc34)nc(Cl)nc12
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InChI
InChI=1S/C20H18ClN5O2S/c21-20-24-17(22-8-12-6-3-5-11-4-1-2-7-13(11)12)15-18(25-20)26(10-23-15)19-16(28)14(27)9-29-19/h1-7,10,14,16,19,27-28H,8-9H2,(H,22,24,25)/t14?,16-,19+/m0/s1
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InChIKey
SBJORAVUWWLBAK-WHJCRDCLSA-N
Physicochemical Property
logP
3.2122
Rotatable Bonds
4
Heavy Atom Count
29
Polar Areas
96.09
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59356317
ChEMBL ID
CHEMBL3703590
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 24.8 nM
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   LI
   LO
   TS