General Information of the Compound
Compound ID
CP0524235
Compound Name
((3S,4R)-3-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-phenylpyrrolidin-1-yl)(morpholino)methanone
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Structure
Formula
C25H26F6N2O3
Molecular Weight
516.482
Canonical SMILES
C[C@@H](O[C@@H]1CN(C[C@H]1c1ccccc1)C(=O)N1CCOCC1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
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InChI
InChI=1S/C25H26F6N2O3/c1-16(18-11-19(24(26,27)28)13-20(12-18)25(29,30)31)36-22-15-33(23(34)32-7-9-35-10-8-32)14-21(22)17-5-3-2-4-6-17/h2-6,11-13,16,21-22H,7-10,14-15H2,1H3/t16-,21+,22-/m1/s1
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InChIKey
ZNOFAJPWNNWZQC-URZJWIJPSA-N
Physicochemical Property
logP
5.722
Rotatable Bonds
4
Heavy Atom Count
36
Polar Areas
42.01
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44444660
ChEMBL ID
CHEMBL399466
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.16 nM
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   LI
   LO
   TS