General Information of the Compound
Compound ID
CP0524175
Compound Name
2-[1-(Naphthalene-2-sulfonyl)-1H-indol-6-yl]-octahydro-pyrido[1,2-a]pyrazine
    Show/Hide
Structure
Formula
C26H27N3O2S
Molecular Weight
445.588
Canonical SMILES
O=S(=O)(c1ccc2ccccc2c1)n1ccc2ccc(cc12)N1CCN2CCCCC2C1
    Show/Hide
InChI
InChI=1S/C26H27N3O2S/c30-32(31,25-11-9-20-5-1-2-6-22(20)17-25)29-14-12-21-8-10-23(18-26(21)29)28-16-15-27-13-4-3-7-24(27)19-28/h1-2,5-6,8-12,14,17-18,24H,3-4,7,13,15-16,19H2
    Show/Hide
InChIKey
WGXKWEPWWSGXOS-UHFFFAOYSA-N
Physicochemical Property
logP
4.706
Rotatable Bonds
3
Heavy Atom Count
32
Polar Areas
45.55
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 9824783
SID: 14783909
ChEMBL ID
CHEMBL45977
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 3 nM
   TI
   LI
   LO
   TS