General Information of the Compound
Compound ID
CP0524165
Compound Name
5-({[(S)-2-(3-tert-Butyl-5-methyl-benzyloxy)-1-phenyl-ethyl]-methyl-amino}-methyl)-2,4-dihydro-[1,2,4]triazol-3-one
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Structure
Formula
C24H32N4O2
Molecular Weight
408.546
Canonical SMILES
CN(Cc1n[nH]c(=O)[nH]1)[C@H](COCc1cc(C)cc(c1)C(C)(C)C)c1ccccc1
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InChI
InChI=1S/C24H32N4O2/c1-17-11-18(13-20(12-17)24(2,3)4)15-30-16-21(19-9-7-6-8-10-19)28(5)14-22-25-23(29)27-26-22/h6-13,21H,14-16H2,1-5H3,(H2,25,26,27,29)/t21-/m1/s1
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InChIKey
VCYXADWZHUWUAD-OAQYLSRUSA-N
Physicochemical Property
logP
4.09382
Rotatable Bonds
8
Heavy Atom Count
30
Polar Areas
74.01
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 135430679
SID: 15254185
ChEMBL ID
CHEMBL153310
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01410, Substance-P receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.42 nM
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   LI
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