General Information of the Compound
Compound ID
CP0523849
Compound Name
3-(3-chlorophenylsulfonyl)-N-(3-(trifluoromethyl)phenyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
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Structure
Formula
C20H11ClF3N5O2S2
Molecular Weight
509.922
Canonical SMILES
FC(F)(F)c1cccc(Nc2nc3c(nnn3c3ccsc23)S(=O)(=O)c2cccc(Cl)c2)c1
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InChI
InChI=1S/C20H11ClF3N5O2S2/c21-12-4-2-6-14(10-12)33(30,31)19-18-26-17(16-15(7-8-32-16)29(18)28-27-19)25-13-5-1-3-11(9-13)20(22,23)24/h1-10H,(H,25,26)
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InChIKey
DMCNNDMJINSLEI-UHFFFAOYSA-N
Physicochemical Property
logP
5.5876
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
89.25
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 20901273
ChEMBL ID
CHEMBL1170291
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1070 nM
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