General Information of the Compound
Compound ID
CP0523843
Compound Name
3-(3-chlorophenylsulfonyl)-N-((tetrahydrofuran-2-yl)methyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
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Structure
Formula
C18H16ClN5O3S2
Molecular Weight
449.945
Canonical SMILES
Clc1cccc(c1)S(=O)(=O)c1nnn2c3ccsc3c(NCC3CCCO3)nc12
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InChI
InChI=1S/C18H16ClN5O3S2/c19-11-3-1-5-13(9-11)29(25,26)18-17-21-16(20-10-12-4-2-7-27-12)15-14(6-8-28-15)24(17)23-22-18/h1,3,5-6,8-9,12H,2,4,7,10H2,(H,20,21)
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InChIKey
FNIXTLLXGNHQRQ-UHFFFAOYSA-N
Physicochemical Property
logP
3.4161
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
98.48
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 18591268
SID: 99376996
ChEMBL ID
CHEMBL1172728
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 29 nM
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