General Information of the Compound
Compound ID
CP0523436
Compound Name
(E)-3-[4-(1-adamantyl)phenoxy]-N-(3-methylsulfonylphenyl)prop-2-enamide
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Structure
Formula
C26H29NO4S
Molecular Weight
451.588
Canonical SMILES
CS(=O)(=O)c1cccc(NC(=O)\C=C\Oc2ccc(cc2)C23CC4CC(CC(C4)C2)C3)c1
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InChI
InChI=1S/C26H29NO4S/c1-32(29,30)24-4-2-3-22(14-24)27-25(28)9-10-31-23-7-5-21(6-8-23)26-15-18-11-19(16-26)13-20(12-18)17-26/h2-10,14,18-20H,11-13,15-17H2,1H3,(H,27,28)/b10-9+
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InChIKey
JSJBCCNMJRDGEU-MDZDMXLPSA-N
Physicochemical Property
logP
5.0891
Rotatable Bonds
6
Heavy Atom Count
32
Polar Areas
72.47
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56967308
SID: 135687596
ChEMBL ID
CHEMBL2178414
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02791, Hypoxia-inducible factor 1-alpha
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 1180 nM
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