General Information of the Compound
Compound ID
CP0522866
Compound Name
17beta-Hydroxy-11beta-[4-(1-oxo-4-methoxycarbonyl-N-methylbutylamino)-phenyl]-17alpha-(1-propinyl)-estra-4,9-dien-3-one
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Structure
Formula
C34H41NO5
Molecular Weight
543.704
Canonical SMILES
COC(=O)CCCC(=O)N(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
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InChI
InChI=1S/C34H41NO5/c1-5-18-34(39)19-17-29-27-15-11-23-20-25(36)14-16-26(23)32(27)28(21-33(29,34)2)22-9-12-24(13-10-22)35(3)30(37)7-6-8-31(38)40-4/h9-10,12-13,20,27-29,39H,6-8,11,14-17,19,21H2,1-4H3/t27-,28+,29-,33-,34-/m0/s1
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InChIKey
CXYQYPUDCUMBCW-BDOGIOJZSA-N
Physicochemical Property
logP
5.6466
Rotatable Bonds
6
Heavy Atom Count
40
Polar Areas
83.91
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25233750
SID: 57585713
ChEMBL ID
CHEMBL449367
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01172, Progesterone receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  1
1
IC50 = 1.55 nM
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