General Information of the Compound
Compound ID
CP0522767
Compound Name
10-(benzenesulfonyl)-N-(3,5-dimethyladamantan-1- yl)-5-thia-1,8,11,12- tetraazatricyclo[7.3.0.0^{2,6}]dodeca- 2(6),3,7,9,11-pentaen-7-amine
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Structure
Formula
C25H27N5O2S2
Molecular Weight
493.658
Canonical SMILES
CC12CC3CC(C)(C1)CC(C3)(C2)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1ccccc1
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InChI
InChI=1S/C25H27N5O2S2/c1-23-10-16-11-24(2,13-23)15-25(12-16,14-23)27-20-19-18(8-9-33-19)30-21(26-20)22(28-29-30)34(31,32)17-6-4-3-5-7-17/h3-9,16H,10-15H2,1-2H3,(H,26,27)
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InChIKey
OVSCYWFISNESPC-UHFFFAOYSA-N
Physicochemical Property
logP
5.3327
Rotatable Bonds
4
Heavy Atom Count
34
Polar Areas
89.25
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 49799685
ChEMBL ID
CHEMBL1173209
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
IC50 = 56.7 nM
   TI
   LI
   LO
   TS
2
Ki = 26.3 nM
   TI
   LI
   LO
   TS