General Information of the Compound
Compound ID
CP0522278
Compound Name
(S)-N-ethyl-N-(1-(3-(4-methoxyphenyl)-3-(4-(methylsulfonyl)phenyl)propyl)piperidin-4-yl)-2-(4-(methylsulfonyl)phenyl)acetamide
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Structure
Formula
C33H42N2O6S2
Molecular Weight
626.841
Canonical SMILES
CCN(C1CCN(CC[C@@H](c2ccc(OC)cc2)c2ccc(cc2)S(C)(=O)=O)CC1)C(=O)Cc1ccc(cc1)S(C)(=O)=O
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InChI
InChI=1S/C33H42N2O6S2/c1-5-35(33(36)24-25-6-14-30(15-7-25)42(3,37)38)28-18-21-34(22-19-28)23-20-32(26-8-12-29(41-2)13-9-26)27-10-16-31(17-11-27)43(4,39)40/h6-17,28,32H,5,18-24H2,1-4H3/t32-/m0/s1
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InChIKey
MFRAZCUYDKFADY-YTTGMZPUSA-N
Physicochemical Property
logP
4.5798
Rotatable Bonds
12
Heavy Atom Count
43
Polar Areas
101.06
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 16073664
ChEMBL ID
CHEMBL378035
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 132 nM
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