General Information of the Compound
Compound ID
CP0520980
Compound Name
(E)-3-[6-(3,5-dihydroxy-4-pyridin-2-ylphenoxy)pyridin-3-yl]-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]prop-2-enamide
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Structure
Formula
C38H36N4O6
Molecular Weight
644.728
Canonical SMILES
COc1cc2CCN(CCc3ccc(NC(=O)\C=C\c4ccc(Oc5cc(O)c(c(O)c5)-c5ccccn5)nc4)cc3)Cc2cc1OC
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InChI
InChI=1S/C38H36N4O6/c1-46-34-19-27-15-18-42(24-28(27)20-35(34)47-2)17-14-25-6-10-29(11-7-25)41-36(45)12-8-26-9-13-37(40-23-26)48-30-21-32(43)38(33(44)22-30)31-5-3-4-16-39-31/h3-13,16,19-23,43-44H,14-15,17-18,24H2,1-2H3,(H,41,45)/b12-8+
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InChIKey
DJLPXIBLGXRMRA-XYOKQWHBSA-N
Physicochemical Property
logP
6.617
Rotatable Bonds
11
Heavy Atom Count
48
Polar Areas
126.27
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
9
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156021243
ChEMBL ID
CHEMBL4647036
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000113 SW620/AD300 Homo sapiens (Human)  1
1
IC50 = 780 nM
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